Steroid 5-reductase (5AR) is a membrane-bound protein that converts steroid hormones like testosterone, progesterone, and androstenedione into their respective 5-reduced metabolites, 5-dihydrotestosterone (DHT), 5-dihydroprogesterone (DHP), and 5-androstenedione. Humans have three SRD5A1, SRD5A2, and SRD5A3 5AR isoforms. SRD5A1 and SRD5A2 function in humans to reduce steroid dosage by 5 percent. DHT plays a role in the activation of androgen receptors and is a more potent androgen than testosterone.
The inactivating mutations in 5αR2 lead to disorders of sexual development. The regulation of 5AR is important for the treatment of benign prostate hyperplasia (BPH) and prostate cancer (PC), and 5AR inhibitors are widely used for the treatment of androgen-dependent benign or malignant prostatic diseases.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V1808 | Dutasteride (GG 745; GI 198745) | 164656-23-9 | Dutasteride (also known as GI198745, GG-745; trade names: Avodart, Avidart) is a potent dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). |
|
V1809 | Finasteride (MK-906) | 98319-26-7 | Finasteride (also known as MK-906)is a potent, reversible, and orally bioactive inhibitor of the rat typeII 5 alpha-reductase with Ki of 10.2 nM, used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB). |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
