The primary receptors on which clonidine and other imidazolines act are imidazoline receptors. The three classes of imidazoline receptors are as follows: I2 receptor is an allosteric binding site for monoamine oxidase and is involved in pain modulation and neuroprotection. I3 receptor controls insulin secretion from pancreatic beta cells. I1 receptor mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure. I1-imidazoline receptors that have been activated cause phosphatidylcholine to be hydrolyzed into DAG. Arachidonic acid and downstream eicosanoids are second messengers that are synthesized in response to elevated DAG levels. Additionally, the sodium-hydrogen antiporter is blocked, and catecholamine synthesis enzymes are stimulated. Given that its signaling pathways are comparable to those of interleukins, the I1-imidazoline receptor may be a member of the neurocytokine receptorfamily.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V4462 | BU-224 HCL | 205437-64-5 | BU224 HCl is a selective, high-affinity imidazoline I2 receptor ligand with Ki of 2.1 nM. |
|
V4463 | BU-226 HCL | 1186195-56-1 | BU226 (BU-226) is an imidazoline receptor ligand withKi of 1.4 nM for I2 and an IC50 of 534.5 nM for I1. |
|
V2386 | Moxonidine (BDF5895) | 75438-57-2 | Moxonidine (also known as BDF5895) is a potent and selective agonist at the imidazoline receptor subtype 1, and is used as centrally active antihypertensive agent. |
|
V70497 | Moxonidine-d4 (Moxonidine d4) | 1794811-52-1 | Moxonidine-d4 is the deuterated form of Moxonidine. |
|
V1921 | Rilmenidine Phosphate | 85409-38-7 | Rilmenidine Phosphate, the water soluble form of Rilmenidine, is a potent and selective imidazoline receptor agonist used for the treatment of hypertension. |
|
V70496 | RX 801077 (2 BFI free base) | 72583-92-7 | RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist/activator with a Ki of 70.1 nM. |
|
V70495 | RX 801077 hydrochloride (2 BFI) | 89196-95-2 | RX 801077 HCl (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist/activator with a Ki of 70.1 nM. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
