Reverse transcription, also known as cDNA synthesis from an RNA template, is carried out by reverse transcriptases (RTs), an enzyme. To direct the synthesis of the first strand cDNA, reverse transcriptases (RTs) combine an RNA template with a brief primer complementary to the 3' end of the RNA.
Reverse transcriptase, an HIV enzyme, is blocked by nucleoside reverse transcriptase inhibitors (NRTIs). HIV reverse transcriptase is bound to and blocked by non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcription is the process by which HIV turns RNA into DNA. HIV cannot replicate when reverse transcriptase and reverse transcription are blocked.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V3660 | Azvudine (RO-0622) | 1011529-10-4 | Azvudine (formerly known as FNC; RO-0622; RO0622) is a novel and potent nucleoside reverse transcriptase inhibitor (NRTI) that has been approved in 2021 in China for the treatment of HIV infection. |
|
V30705 | Cyclouridine (2,2'-Anhydrouridine) | 3736-77-4 | 2,2'-Anhydrouridine may be utilized in anti-tumor and anti-viral research. |
|
V13914 | Depulfavirine (RO-0335) | 867365-76-2 | RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor. |
|
V79792 | HIV-1 inhibitor-49 | HIV-1 inhibitor-49 is an orally bioactive HIV-1 inhibitor and a HEPT analogue. | |
|
V31836 | Tenofovir hydrate (GS 1278) | 206184-49-8 | Tenofovir hydrate(formerly also known as GS-1278; PMPA; TDF) is an approved anti-HIV drug that blocks reverse transcriptase and hepatitis B virus infections. |
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