Cytochrome P450

Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. The p450 superfamily, which has members in every class of organisms, including Archaea, is thought to have descended from an ancestor gene that existed more than 3 billion years ago.One of the biggest multigene families has subsequently been created as a result of repeated gene duplications. These enzymes stand out for the variety of reactions they catalyze as well as the variety of chemically diverse substrates they act on. The oxidative, peroxidative, and reductive metabolism of endogenous and exogenous substrates like environmental toxins, agrochemicals, plant allelochemicals, steroids, prostaglandins, and fatty acids is supported by cytochrome p450s. Drug interactions and interindividual variability in drug metabolism are two of the most important issues in clinical pharmacology, and cytochrome p450s in humans are best known for their central role in phase I drug metabolism.

Cytochrome P450 related products

Structure Cat No. Product Name CAS No. Product Description
V60135 CYP1B1-IN-4 2685779-55-7 CYP1B1-IN-4 is a selective CYP1B1 (IC50=0.2 nM) 2,4-diarylthiazole compound.
V73938 (3S,5S)-Atorvastatin sodium salt (Atorvastatin impurity sodium salt) 1428118-38-0 (3S,5S)-Atorvastatin sodium salt is a pregnane X receptor (PXR) activator and the inactive enantiomer of Atorvastatin.
V73959 (R)-6',7'-Dihydroxybergamottin ((R)-6',7'-DHB) 264234-05-1 (R)-6',7'-Dihydroxybergamomottin ((R)-6',7'-DHB) is a competitive inhibitor of human and rat CYP1A1 activity, with Kis of 55 μM and 1.72 μM, respectively.
V73942 (R)-Mephenytoin ((-)-Mephenytoin) 71140-51-7 (R)-Mephenytoin ((-)-Mephenytoin) is the R-enantiomer of mephenytoin.
V73972 (S)-Mephenytoin ((+)-Mephenytoin) 70989-04-7 (S)-Mephenytoin ((+)-Mephenytoin) is an anticonvulsant (antiepileptic/antiseizure).
V73928 (±)-N-3-Benzylnirvanol ((+/-)-N-3-Benzylnirvanol) 93879-40-4 (±)-N-3-Benzylnirvanol is a racemic mixture (racemate) of (+)-N-3-Benzylnirvanol and (-)-N-3-Benzylnirvanol.
V73976 1'-Hydroxy bufuralol 57704-16-2 1'-Hydroxy bufuralol is the major metabolite of bufuralol and reflects the activity of CYP2D.
V4419 1-Aminobenzotriazole 1614-12-6 1-Aminobenzotriazole (also known as ABT; 3-Aminobenzotriazole) has been used widely as a nonselective in vitro and in vivo inhibitor of cytochrome P450 enzymes.
V73931 1-Ethynylpyrene 34993-56-1 1-Ethynylpyrene is an inhibitor (blocker/antagonist) of cytochrome P450 1A1, 1A2 and 2B1 with IC50 of 0.18, 0.32 and 0.04 μM respectively.
V60140 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2-[(4-fluorophenyl)methyl]- 186299-00-3 hCYP3A4 Fluorogenic Substratum 1 is a potent form of hCYP3A4 fluid.Having a Km value of 0.36 μM.
V73962 2,6-Dimethylquinoline 877-43-0 2,6-Dimethylquinoline, a natural component from Peucedantu praeruptorum roots, is an inhibitor (blocker/antagonist) of CYP1A2 with IC50 of 3.3 µM.
V73948 20-HETE inhibitor-1 2472030-28-5 20-HETE inhibitor-1 (comp 83) is an inhibitor (blocker/antagonist) of 20-HETE synthesis.
V9500 3-CETC 117620-77-6 3-CETC (3-Cyano-7-ethoxycoumarin) is a novel and potent fluorescent CYP1A1 &1A2 substrate.
V73963 4,5-Dimethoxycanthin-6-one 18110-87-7 4,5-Dimethoxycanthin-6-one is a potent, noncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with IC50 of 1.7 μM and a Ki of 2.6 μM.
V73979 5,7,2',6'-Tetrahydroxyflavone 82475-00-1 5,7,2',6'-Tetrahydroxyflavone is a naturally occurring flavonoid that can inhibit hepatic testosterone 6β-hydroxylation (CYP3A4) activity with IC50 of 7.8 μM.
V40552 5,7-Dimethoxyflavone 21392-57-4 5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora and has anti-obesity, anti~inflammatory and anti-tumor effects.
V73981 6',7'-Dihydroxybergamottin (6',7'-DHB) 145414-76-2 6',7'-Dihydroxybergamomottin (6',7'-DHB) is a furanocoumarin that can inhibit CYP3A4 and is present in grapefruit juice and Seville orange juice.
V73957 7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) 220001-53-6 7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate.
V73961 7-Ethoxyresorufin (7-ethoxyresorufin; Resorufin ethyl ether) 5725-91-7 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorescent substrate and competitive inhibitor of cytochrome P450 (especially CYP1A1).
V70676 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate 67667-71-4 8α-(2-Methylacryloyloxy)-hirsutinolide-13-O-acetate is an irreversible CYP2A6 inhibitor (antagonist) with IC50 of 8.64 μM and 22.3 μM for preincubation and co-incubation, respectively.
Contact Us