|
V80838
|
8BTC |
|
8BTC (compound 4w) is a potent covalent Notum inhibitor (antagonist) with IC50 of 2.5 nM. |
|
V69164
|
ABC99 |
2331255-53-7 |
BC99 is an N-hydroxyhydantoin (NHH) carbamate that selectively inhibits the Wnt-deacylating enzyme NOTUM (IC50=13 nM). |
|
V69166
|
Box5 |
1206604-29-6 |
Box5 is a potent Wnt5a antagonist. |
|
V77189
|
Box5 TFA |
|
Box5 TFA is a potent Wnt5a antagonist. |
|
V69165
|
Carboxylesterase-IN-3 |
2764748-92-5 |
Carboxylesterase-IN-3 (compound 4y) is a potent Carboxylesterase Notum inhibitor (antagonist) with IC50 less than or equal to 10 nM. |
|
V69169
|
Cardionogen 1 (CDNG1/vuc230) |
577696-37-8 |
Cardionogen 1 (CDNG1/vuc230) is a Wnt signaling pathway inhibitor that can slow down Myc-induced liver tumorigenesis. |
|
V77001
|
Foxy-5 TFA |
|
Foxy-5 TFA is a WNT5A agonist, a mimetic peptide of WNT5A, and a non-classical member of the Wnt family. |
|
V69163
|
Ipafricept (OMP-54F28; FZD8-Fc) |
1391727-24-4 |
Ipafricept (OMP-54F28; FZD8-Fc) is a first-in-class recombinant fusion protein consisting of the extracellular portion of the human Frizzled-8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands. |
|
V69168
|
IWP-2-V2 |
877618-79-6 |
IWP-2-V2 is an IWP-2 analog that retains activity on the Wnt/β-catenin pathway. |
|
V76844
|
KY-02327 acetate |
|
KY-02327 acetate is a metabolically stable analog of KY-02061 and a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. |
|
V67511
|
NLS-StAx-h |
2872559-21-0 |
NLS-StAx-h is a selective, cell-permeable (penetrable), immobilized peptide inhibitor of Wnt signaling with IC50 of 1.4 μM. |
|
V69167
|
Pin1 modulator 1 |
301688-74-4 |
Pin1 modulator 1 (compound IIb-219) is a modulator that specifically targets β-Catenin and inhibits the Wnt pathway. |
|
V69173
|
Porcn-IN-2 |
1900754-65-5 |
Porcn-IN-2 (Example 107) is a Wnt inhibitor (antagonist) with IC50 of 0.05 nM. |
|
V67518
|
Sempervirine nitrate |
17994-15-9 |
Sempervirine is an alkaloid derived from Gelsemium elegans Benth. |
|
V69171
|
Tabituximab barzuxetan (exclude Y90) (OTSA101-DTPA; OTSA101-DTPA-90Y; OTSA101-SS01) |
1612758-88-9 |
Tabituximab barzuxetan (exclude Y90) is a radioimmunoconjugate consisting of a humanized monoclonal antibody (mAb) targeting FZD-10 (OTSA-101). |
|
V69170
|
Vantictumab (OMP-18R5) |
1345009-45-1 |
Vantictumab (OMP-18R5) is a fully human IgG2 monoclonal antibody (mAb). |
|
V69172
|
Wnt pathway inhibitor 3 |
663213-98-7 |
Wnt pathway inhibitor 3 is a potent AC1 inhibitor (antagonist) with IC50 of 45 nM. |
|
V67509
|
YW2036 |
2131223-92-0 |
YW2036 (compound 2a) is a potent inhibitor of the Wnt/β-Catenin signaling pathway with IC50 of 637 nM. |
|
V69126
|
Zamaporvint (RXC004) |
1900754-56-4 |
Zamaporvint (RXC004) is an orally bioactive, selective Wnt inhibitor. |